Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-ß clearance in human astrocytes.

Fong, Lauren K; Yang, Max M; Dos Santos Chaves, Rodrigo; Reyna, Sol M; Langness, Vanessa F; Woodruff, Grace; Roberts, Elizabeth A; Young, Jessica E; Goldstein, Lawrence S B

Fong, Lauren K; Yang, Max M; Dos Santos Chaves, Rodrigo; Reyna, Sol M; Langness, Vanessa F; Woodruff, Grace; Roberts, Elizabeth A; Young, Jessica E; Goldstein, Lawrence S B.

Afiliación

Fong LK; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093.
Yang MM; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093.
Dos Santos Chaves R; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093.
Reyna SM; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093.
Langness VF; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093.
Woodruff G; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093.
Roberts EA; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093.
Young JE; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Department of Pathology and Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195.
Goldstein LSB; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093; Sanford Consortium for Regenerative Medicine, La Jolla, California 92093; Department of Neurosciences, University of California at San Diego, La Jolla, California 92093. Electronic addre

J Biol Chem ; 293(29): 11341-11357, 2018 07 20.

Article en En | MEDLINE | ID: mdl-29858247

Asunto(s)

Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Astrocitos/metabolismo; Colesterol/metabolismo; Lipoproteínas/metabolismo; Precursor de Proteína beta-Amiloide/genética; Astrocitos/citología; Sistemas CRISPR-Cas; Línea Celular; Endocitosis; Humanos; Células Madre Pluripotentes Inducidas/citología; Células Madre Pluripotentes Inducidas/metabolismo; Receptores de LDL/metabolismo; Proteínas de Unión a los Elementos Reguladores de Esteroles/metabolismo

Palabras clave

Alzheimer disease; amyloid precursor protein (APP); amyloid-beta (Aß); astrocyte; cholesterol metabolism; induced pluripotent stem cell (iPS cell) (iPSC); lipoprotein metabolism; lipoprotein receptor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitos / Colesterol / Péptidos beta-Amiloides / Precursor de Proteína beta-Amiloide / Lipoproteínas Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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