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Cancer Navigation Strategy for Endocrine Therapy-Resistant Breast Tumors.
Nakao, Mitsuyoshi; Fujiwara, Saori; Iwase, Hirotaka.
Afiliación
  • Nakao M; Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan. Electronic address: mitnakao@kumamoto-u.ac.jp.
  • Fujiwara S; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan; Hormone Action and Oncogenesis Section, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Iwase H; Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Trends Cancer ; 4(6): 404-407, 2018 06.
Article en En | MEDLINE | ID: mdl-29860984
ABSTRACT
Estrogen receptor (ER) α-positive breast cancers frequently acquire resistance to endocrine therapy. However, recent studies found that a fraction of these tumors overexpress ER, and that estrogen treatment induces apoptosis. We propose a 'cancer navigation' strategy to systematically lead resistant cells to growth arrest and apoptosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Apoptosis / Resistencia a Antineoplásicos / Antineoplásicos Hormonales Límite: Female / Humans Idioma: En Revista: Trends Cancer Año: 2018 Tipo del documento: Article
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Apoptosis / Resistencia a Antineoplásicos / Antineoplásicos Hormonales Límite: Female / Humans Idioma: En Revista: Trends Cancer Año: 2018 Tipo del documento: Article