A Photochemical Two-Step Formal [5+2] Cycloaddition: A Condensation/Ring-Expansion Approach to Substituted Azepanes.
Synlett
; 28(20): 2755-2758, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-29861552
ABSTRACT
Seven-membered nitrogen-containing heterocycles are considerably underrepresented in the literature compared to their five- and six-membered analogues. Herein, we report a relatively understudied photochemical rearrangement of N-vinylpyrrolidinones to azepin-4-ones in good yields. This transformation allows for the conversion of readily available pyrrolidinones and aldehydes to densely functionalized azepane derivatives in a facile two step procedure.
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01-internacional
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MEDLINE
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En
Revista:
Synlett
Año:
2017
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Article