Multicenter study of QuantiFERON®-TB Gold Plus in patients with active tuberculosis.
Int J Tuberc Lung Dis
; 22(6): 617-621, 2018 06 01.
Article
en En
| MEDLINE
| ID: mdl-29862944
ABSTRACT
SETTING:
QuantiFERON®-TB Gold Plus (QFT-Plus), recently approved for use in the United States, is a new-generation QuantiFERON assay that differs from its predecessors in that it uses an additional antigen tube containing peptides to elicit both CD8+ and CD4+ T-lymphocyte responses.OBJECTIVE:
To assess the sensitivity of QFT-Plus compared with QuantiFERON®-TB Gold In-Tube (QFT-GIT) in participants with active TB.DESIGN:
Adult patients with active TB at three US and two Japanese sites were eligible for this study if they had culture-confirmed TB and were either untreated or had received îº14 days of anti-tuberculosis treatment.RESULTS:
We enrolled 164 participants, nine of whom had indeterminate results. Excluding indeterminate values, there were 150 QFT-GIT-positive results among 159 tests and 146 QFT-Plus-positive results among 157 tests, with sensitivities of respectively 94.3% (95%CI 89.5-97.4) and 93.02% (95%CI 87.8-96.5%). The estimated sensitivities for the two tests were not significantly different (P = 0.16). Overall test agreement was 98.7%, with a κ statistic of 0.89 (95%CI 0.75-1.00).CONCLUSION:
In this multisite study, we found that QFT-Plus had similar sensitivity to QFT-GIT in adult patients with active TB.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Linfocitos T CD4-Positivos
/
Linfocitos T CD8-positivos
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Ensayos de Liberación de Interferón gamma
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do norte
/
Asia
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Año:
2018
Tipo del documento:
Article