Peripheral and central autonomic nervous system: does the sympathetic or parasympathetic nervous system bear the brunt of the pathology during the course of sporadic PD?
Cell Tissue Res
; 373(1): 267-286, 2018 07.
Article
en En
| MEDLINE
| ID: mdl-29869180
ABSTRACT
It is a well-established fact that the sympathetic, parasympathetic and enteric nervous systems are affected at early stages in Parkinson's disease (PD). However, it is not yet clarified whether the earliest pathological events preferentially occur in any of these three divisions of the autonomic nervous system (ANS). Significant involvement of the peripheral autonomic nervous system of the heart and gastrointestinal tract has been documented in PD. Accumulating evidence suggests that the PD pathology spreads centripetally from the peripheral to central nervous system through autonomic nerve fibers, implicating the ANS as a major culprit in PD pathogenesis and a potential target for therapy. This study begins with a brief overview of the structures of the central and peripheral autonomic nervous system and then outlines the major clinicopathological manifestations of cardiovascular and gastrointestinal disturbances in PD.
Palabras clave
Autonomic nervous system; Cardiovascular autonomic test; Enteric nervous system; Gastrointestinal system; Heart rate variability; Lewy body; Orthostatic hypotension; Parasympathetic; Parkinson's disease; Sympathetic; Tyrosine hydroxylase; meta-Iodobenzylguanidine cardiac scintigraphy; α-Synuclein
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Parasimpático
/
Enfermedad de Parkinson
/
Sistema Nervioso Autónomo
/
Sistema Nervioso Simpático
Límite:
Humans
Idioma:
En
Revista:
Cell Tissue Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Japón