Gold-Catalyzed C-S Aryl-Group Transfer in Zinc Finger Proteins.
Angew Chem Int Ed Engl
; 57(30): 9305-9309, 2018 07 20.
Article
en En
| MEDLINE
| ID: mdl-29870126
ABSTRACT
Reaction of the Au-C N chelate [Au(bnpy)Cl2 ] with the full-length zinc finger (ZnF; ZnCys3 His) of HIV nucleocapsid protein NCp7 results in C-S aryl transfer from the AuIII organometallic species to a cysteine of the ZnF. The reaction is general and occurs even for fingerâ
3 of the transcription factor Sp1, containing a ZnCys2 His2 coordination sphere. This reaction is the first demonstration of group transfer from a coordination compound to biologically important zinc fingers, and is especially noteworthy for the ZnCys2 His2 transcription factors. The work expands the corpus of organometallic species which can efficiently modify biomolecules through C-atom transfer. The electronic features of the gold compound leading to this unexpected reaction were explored by X-ray absorption spectroscopy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azufre
/
Carbono
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VIH
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Proteínas de la Nucleocápside
/
Dedos de Zinc CYS2-HIS2
/
Oro
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos