Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
J Med Chem
; 61(20): 8947-8980, 2018 10 25.
Article
en En
| MEDLINE
| ID: mdl-29870668
ABSTRACT
DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication, recombination, and repair. Despite the popular applications of topo II inhibitors in cancer therapy, there is still an urgent need to upgrade topo II inhibitors to cope with drug resistance and severe adverse effects. Accordingly, novel topo II catalytic or multitarget topo II inhibitors are gaining more attention and make it possible to ease the toxic limitations of topo II poisons. In this review, medicinal chemistry approaches are mainly discussed toward the development of potent topo II inhibitors with low toxicities.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN-Topoisomerasas de Tipo II
/
Descubrimiento de Drogas
/
Inhibidores de Topoisomerasa II
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2018
Tipo del documento:
Article