Depression may be a risk factor for coronary heart disease in midlife women <65â¯years: A 9-year prospective cohort study.
Int J Cardiol
; 271: 8-12, 2018 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-29880298
ABSTRACT
OBJECTIVE:
Depression has been suggested as a risk factor for coronary heart disease (CHD). However, whether the risk may be affected by age is unknown. We seek to assess the difference in long-term CHD risk between younger (<65) and older (≥65) women with depressive symptoms.METHODS:
Between June and August 2004, 1995 women presenting for routine mammography were enrolled to the primary study on breast arterial calcification. In 2005 (year 2), each woman completed a validated depression screening questionnaire. A similar questionnaire was mailed to each participant at year 4, 5, and 10 to obtain follow-up data (demographic and CHD risk factors) and record any change in CHD status.RESULTS:
Of 1084 women who returned surveys at year 10, 998 had no history of CHD and answered depression screening questions at year 2 as well as questions about CHD events at year 10. Of 185 out of 998 (18.5%) who had positive depression screening at year 2, 24 (13.0%) developed ≥1 CHD events by year 10, which is significantly higher than the incidence of 6.5% (53/813) in control group (pâ¯<â¯0.001). With CHD risk factors including age adjusted in a logistic regression model, depression was the only significant predictive factor for CHD in women aged <65 (ORâ¯=â¯6.56, 95% CI 1.07-40.09, pâ¯=â¯0.042). However, in women aged ≥65, age was the only significant predictive factor for CHD.CONCLUSION:
A history of depression may increase the risk of CHD over 9â¯years of follow-up, and more prominently in midlife women aged <65â¯years.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad Coronaria
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Depresión
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
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Qualitative_research
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Int J Cardiol
Año:
2018
Tipo del documento:
Article