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Intratympanic gadolinium magnetic resonance imaging supports the role of endolymphatic hydrops in the pathogenesis of immune-mediated inner-ear disease.
Lobo, D; Tuñón, M; Villarreal, I; Brea, B; García-Berrocal, J R.
Afiliación
  • Lobo D; Department of Otolaryngology,Hospital Universitario El Escorial,Universidad Francisco de Vitoria,Madrid,Spain.
  • Tuñón M; Department of Radiology,Hospital Universitario Puerta de Hierro,Universidad Autónoma de Madrid,Spain.
  • Villarreal I; Department of Otolaryngology,Hospital Universitario Puerta de Hierro,Universidad Autónoma de Madrid,Spain.
  • Brea B; Department of Radiology,Hospital Universitario Puerta de Hierro,Universidad Autónoma de Madrid,Spain.
  • García-Berrocal JR; Department of Otolaryngology,Hospital Universitario Puerta de Hierro,Universidad Autónoma de Madrid,Spain.
J Laryngol Otol ; 132(6): 554-559, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29888688
ABSTRACT

OBJECTIVE:

To evaluate the presence of endolymphatic hydrops in patients with immune-mediated inner-ear disease.

METHODS:

The presence of endolymphatic hydrops was prospectively evaluated in 17 patients clinically diagnosed with secondary (n = 5) or primary (n = 12) immune-mediated inner-ear disease, who attended the ENT department of a tertiary care centre for evaluation or treatment over the previous year. All patients underwent magnetic resonance imaging of the temporal bone.

RESULTS:

Intratympanic gadolinium three-dimensional magnetic resonance imaging diagnosed hydrops in 11 of 12 patients with primary immune-mediated inner-ear disease (92 per cent). Of these, seven patients (64 per cent) presented only cochlear (n = 5) or predominantly cochlear (n = 2) hydrops. A positive magnetic resonance imaging result was observed in only one of five patients with secondary immune-mediated inner-ear disease (20 per cent).

CONCLUSION:

This study confirms the presence of endolymphatic hydrops in immune-mediated inner-ear disease patients. The virtual absence of hydrops in patients with secondary immune-mediated inner-ear disease is remarkable, although firm conclusions cannot be drawn; this should be explored in a multicentre study with a larger sample of patients. A different immune reaction without development of endolymphatic hydrops should not be ruled out in secondary immune-mediated inner-ear disease patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Hidropesía Endolinfática / Enfermedades del Laberinto Tipo de estudio: Etiology_studies / Observational_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Laryngol Otol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Hidropesía Endolinfática / Enfermedades del Laberinto Tipo de estudio: Etiology_studies / Observational_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Laryngol Otol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: España