PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy.

Wang, Yiyang; Shen, Jieliang; Chen, Yanyang; Liu, Huzhe; Zhou, Hao; Bai, Zhibiao; Hu, Zhenming; Guo, Xiuming

Wang, Yiyang; Shen, Jieliang; Chen, Yanyang; Liu, Huzhe; Zhou, Hao; Bai, Zhibiao; Hu, Zhenming; Guo, Xiuming.

Afiliación

Wang Y; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Shen J; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Chen Y; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Liu H; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Zhou H; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Bai Z; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Hu Z; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China. Electronic address: spinecenter@163.com.
Guo X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China. Electronic address: xmguo813@163.com.

Biochem Biophys Res Commun ; 504(2): 406-414, 2018 10 02.

Article en En | MEDLINE | ID: mdl-29890141

Asunto(s)

Senescencia Celular; Mitofagia; Núcleo Pulposo/citología; Estrés Oxidativo; Fosfohidrolasa PTEN/metabolismo; Proteínas Quinasas/metabolismo; Apoptosis; Autofagia; Proliferación Celular; Humanos; Peróxido de Hidrógeno/farmacología; Potencial de la Membrana Mitocondrial; Mitocondrias/metabolismo; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

Intervertebral disc; Mitophagy; Oxidative stress; PINK1; Senescence

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Senescencia Celular / Estrés Oxidativo / Fosfohidrolasa PTEN / Mitofagia / Núcleo Pulposo Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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