Quetiapine Excretion Into Human Breast Milk.
J Clin Psychopharmacol
; 38(4): 362-364, 2018 Aug.
Article
en En
| MEDLINE
| ID: mdl-29912789
ABSTRACT
BACKGROUND:
Risk assessment of the use of quetiapine during breastfeeding is challenging owing to a paucity of data.METHODS:
A pharmacokinetic study was conducted in lactating women who were taking quetiapine. The primary endpoint was to determine quetiapine concentration profiles in milk and estimated infant exposure levels. Multiple milk and a single blood quetiapine concentrations were determined using a highly sensitive liquid chromatography with tandem mass spectroscopy method.RESULTS:
Nine subjects receiving fast-release quetiapine (mean dose, 41 mg/d) were analyzed at steady state. The mean milk/plasma drug concentration ratio at 2-hour postdose was 0.47 (SD, 0.50; range, 0.13-1.67). The mean milk concentration of each patient was 5.7 ng/mL (SD, 4.5; range, 1.4-13.9 ng/mL). The mean infant quetiapine dose via milk per body weight relative to weight-adjusted maternal dose was 0.16 % (SD, 0.08; range, 0.04%-0.35%).CONCLUSIONS:
Infant exposure levels to quetiapine via milk are predicted to be very small.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antipsicóticos
/
Fumarato de Quetiapina
/
Leche Humana
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
J Clin Psychopharmacol
Año:
2018
Tipo del documento:
Article