Derivation of CYP3A4 and CYP2B6 degradation rate constants in primary human hepatocytes: A siRNA-silencing-based approach.

Chan, Christina Y S; Roberts, Owain; Rajoli, Rajith K R; Liptrott, Neill J; Siccardi, Marco; Almond, Lisa; Owen, Andrew

Chan, Christina Y S; Roberts, Owain; Rajoli, Rajith K R; Liptrott, Neill J; Siccardi, Marco; Almond, Lisa; Owen, Andrew.

Afiliación

Chan CYS; Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Roberts O; Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Rajoli RKR; Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Liptrott NJ; Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Siccardi M; Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Almond L; Simcyp (a Certara Company), Blades Enterprise Centre, John Street, Sheffield, S2 4SU, UK.
Owen A; Department of Molecular and Clinical Pharmacology, The University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK. Electronic address: aowen@liv.ac.uk.

Drug Metab Pharmacokinet ; 33(4): 179-187, 2018 Aug.

Article en En | MEDLINE | ID: mdl-29921509

Asunto(s)

Citocromo P-450 CYP2B6/metabolismo; Citocromo P-450 CYP3A/metabolismo; Hepatocitos/citología; Hepatocitos/metabolismo; Proteolisis; Interferencia de ARN; ARN Interferente Pequeño/genética; Células Cultivadas; Citocromo P-450 CYP2B6/genética; Citocromo P-450 CYP3A/genética; Humanos; Cinética; ARN Mensajero/genética; ARN Mensajero/metabolismo; ARN Interferente Pequeño/metabolismo

Palabras clave

Cytochrome P450; Degradation rate constant; Drugdrug interactions; Half-life; Human hepatocytes; Mechanism-based inhibition; Physiologically-based pharmacokinetic modelling; Small-interfering RNA; Time-dependent inhibition

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatocitos / ARN Interferente Pequeño / Interferencia de ARN / Citocromo P-450 CYP3A / Proteolisis / Citocromo P-450 CYP2B6 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google