A novel molecular mechanism of microRNA-21 inducing pulmonary fibrosis and human pulmonary fibroblast extracellular matrix through transforming growth factor ß1-mediated SMADs activation.

Zhou, Jun; Xu, Qianqian; Zhang, Qiudi; Wang, Zhigang; Guan, Shuhong

Zhou, Jun; Xu, Qianqian; Zhang, Qiudi; Wang, Zhigang; Guan, Shuhong.

Afiliación

Zhou J; Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, Changzhou, China.
Xu Q; Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, Changzhou, China.
Zhang Q; Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, Changzhou, China.
Wang Z; Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, Changzhou, China.
Guan S; Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University/The First People's Hospital of Changzhou, Changzhou, China.

J Cell Biochem ; 119(9): 7834-7843, 2018 09.

Article en En | MEDLINE | ID: mdl-29943845

Asunto(s)

Bleomicina/efectos adversos; Matriz Extracelular/metabolismo; MicroARNs/genética; Fibrosis Pulmonar/genética; Receptor Tipo I de Factor de Crecimiento Transformador beta/metabolismo; Proteínas Smad/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo; Animales; Línea Celular; Núcleo Celular/metabolismo; Modelos Animales de Enfermedad; Fibroblastos/citología; Fibroblastos/efectos de los fármacos; Fibroblastos/metabolismo; Humanos; Ratones; Regiones Promotoras Genéticas; Fibrosis Pulmonar/inducido químicamente; Fibrosis Pulmonar/metabolismo; Proteína Smad2/metabolismo; Proteína smad3/metabolismo; Proteína Smad4/metabolismo

Palabras clave

SMAD2/3/4; extracellular matrix; microRNA-21; pulmonary fibrosis; transforming growth factor ß 1

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Bleomicina / MicroARNs / Proteínas Smad / Matriz Extracelular / Factor de Crecimiento Transformador beta1 / Receptor Tipo I de Factor de Crecimiento Transformador beta Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Cell Biochem Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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