Cadherins: cellular adhesive molecules serving as signalling mediators.
J Physiol
; 596(17): 3883-3898, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29968384
ABSTRACT
The single pass, transmembrane proteins of the cadherin family have been appreciated as important proteins that regulate intercellular adhesion. In addition to this critical function, cadherins contribute to important signalling events that control cellular homeostasis. Many examples exist of classical, desmosomal and atypical cadherins participating in the regulation of signalling events that control homeostatic functions in cells. Much of the work on cadherin mediated signalling focuses on classical cadherins or on specific disease states such as pemphigus vulgaris. Cadherin mediated signalling has been shown to play critical roles during development, in proliferation, apoptosis, disease pathobiology and beyond. It is becoming increasingly clear that cadherins operate through a range of molecular mechanisms. The diversity of pathways and cellular functions regulated by cadherins suggests that we have only scratched the surface in terms of the roles that these versatile proteins play in signalling and cellular function.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Cadherinas
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Adhesión Celular
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Diferenciación Celular
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Apoptosis
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Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Physiol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos