Stereoselective synthesis of 4ß-acyloxypodophyllotoxin derivatives as insecticidal agents.
J Asian Nat Prod Res
; 21(10): 1028-1041, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-29974799
ABSTRACT
As our ongoing work on research of natural-product-based insecticidal agents, some 4α/ß-acyloxypodophyllotoxin derivatives were synthesized, and were evaluated against the pre-third-instar larvae of B. mori, A. dissimilis and M. separate in vivo at the concentration of 1 mg ml-1, respectively. Among all derivatives, compounds 2 g, h and 4c, d showed more promising insecticidal activities than their precursors - podophyllotoxin and epipodophyllotoxin. Furthermore, derivatives 2 g, h and 4c, d exhibited more relative amicable activities than their precursors - podophyllotoxin and epipodophyllotoxin. This results indicated that 4ß-acyloxy moiety in the podophyllotoxin derivatives was significant for obtaining the more potent compounds.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Podofilotoxina
/
Insecticidas
Límite:
Animals
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China