Endometrial cancer prognosis correlates with the expression of L1CAM and miR34a biomarkers.
J Exp Clin Cancer Res
; 37(1): 139, 2018 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-29980240
ABSTRACT
BACKGROUND:
Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several human carcinomas and has recently been described as a new marker for endometrial and ovarian carcinomas. The aim of this study was to determine the relevance of L1CAM in recurrent EC.METHODS:
In this work we have analyzed, by immunohistochemical and RT-qPCR analysis, the expression of L1CAM in a cohort of 113 endometrial cancers at different stages, which 50% have relapsed. As a predictor of good outcome, the tumors were also analyzed for the expression of miR-34a, a post-transcriptional regulator of L1CAM.RESULTS:
Among metastatic EC, the highest levels (60%) and the median level (24%) of L1CAM in tumors correlate with the progression, suggesting that the expression of this molecule is linked to the tumor component most involved in metastatic processes. We also found an inverse correlation between miR-34a and L1CAM protein expression, suggesting that miR-34a is a positive prognostic marker of EC.CONCLUSIONS:
Our results demonstrate the expression of L1CAM and miR-34a in EC as prognostic factors that identify subgroup of patients at high risk of recurrence suggesting for them more aggressive schedules of treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Regulación Neoplásica de la Expresión Génica
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Neoplasias Endometriales
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Molécula L1 de Adhesión de Célula Nerviosa
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MicroARNs
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
/
Aged80
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
J Exp Clin Cancer Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia