Domperidone use and risk of primary liver cancer in the Clinical Practice Research Datalink.
Cancer Epidemiol
; 55: 170-175, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29986235
ABSTRACT
BACKGROUND:
Pronounced sex-disparity in liver cancer suggests a role for hormones, one of which could be prolactin. Stimulation of prolactin production in mice via domperidone has been reported to decrease hepatocarcinogenesis, thus may have chemopreventive potential. To study the effect of domperidone in humans, a large medical records study was conducted.METHODS:
Based in the Clinical Practice Research Datalink, 1921 liver cancer cases and 7681 controls were identified. Conditional logistic regression was employed to estimate odds ratios (OR) and 95% confidence intervals (CI). Domperidone use was analyzed overall, and by number of prescriptions and cumulative dose.RESULTS:
Comparing ever- versus never-use, there was no association between domperidone and liver cancer among men (ORâ¯=â¯1.06, 95% CI 0.76-1.48) or women (ORâ¯=â¯1.21, 95% CI 0.82-1.76). Among men, there was no association with dose or number of prescriptions, while among women who received the highest doses (OR2700 mg vs. 0 mgâ¯=â¯2.52, 95% CI 1.18-5.41, p-trendâ¯=â¯0.02) and greatest number of prescriptions (OR≥11 Rx vs. 0 Rxâ¯=â¯3.17, 95% CI 1.07-9.40, p-trendâ¯=â¯0.02) there was a significantly increased risk, although there was no evidence of heterogeneity in the results by gender.CONCLUSION:
Domperidone use was not associated with decreased liver cancer risk among all study participants. Among women, an increased risk at highest levels of exposure warrants further study.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pautas de la Práctica en Medicina
/
Bases de Datos Factuales
/
Antagonistas de Dopamina
/
Investigación Biomédica
/
Domperidona
/
Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Cancer Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos