Multiparametric radiomics improve prediction of lymph node metastasis of rectal cancer compared with conventional radiomics.
Life Sci
; 208: 55-63, 2018 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-29990485
ABSTRACT
AIMS:
To establish multiparametric radiomics of rectal tumor for the preoperative prediction of lymph node (LN) metastasis. MATERIALS ANDMETHODS:
This prospective study consisted of 115 consecutive patients with rectal carcinoma between April 2015 and April 2017. The multiparametric radiomics scores were extracted from the endorectal ultrasound (ERUS), computed tomography (CT) and shear-wave elastography (SWE) features of the rectal tumor, LN, and peripheral tissues. The three radiomics scores were generated. Further validation as an independent predictor was performed using multivariate logistic regression together with clinical data, and a nomogram was subsequently developed. The predictive performance of the multiparametric radiomics nomogram was compared with that of conventional radiomics. KEYFINDINGS:
All three scores (ERUS, CT, and SWE) were significantly higher in patients with LN metastasis than in patients with negative LN metastasis (all Pâ¯<â¯0.05) in both training and validation set. Multivariate analysis indicated that CT and SWE scores were independent risk variables (odds ratio, ORâ¯=â¯6.764 and 5.482, respectively). In validation cohort, the multiparametric radiomics nomogram showed the highest predictive accuracy for LN metastasis, with a concordance index (C-index) of 0.857 compared with the conventional radiomics nomogram (C-index, 0.703, Pâ¯=â¯0.100), resulting in a significantly improved net reclassification index (NRI) (Pâ¯<â¯0.05) and integrated discriminatory improvement (IDI) (Pâ¯=â¯0.002). Decision curve analysis showed that the multiparametric radiomics nomogram had a higher overall net benefit.SIGNIFICANCE:
Multiparametric radiomics of rectal cancer, which captures blood supply and stiffness phenotypes, is a useful tool for predicting LN metastasis preoperatively and has marked discrimination accuracy compared to conventional radiomics.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Recto
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Adenocarcinoma
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Tomografía Computarizada por Rayos X
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Endosonografía
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Nomogramas
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Diagnóstico por Imagen de Elasticidad
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Imagen Multimodal
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Life Sci
Año:
2018
Tipo del documento:
Article
País de afiliación:
China