Epoxygenase Inhibitors Attenuate the Stimulatory Effect of Glutoxim on Na+ Transport in Frog Skin.
Dokl Biochem Biophys
; 480(1): 152-154, 2018 May.
Article
en En
| MEDLINE
| ID: mdl-30008098
ABSTRACT
Using voltage-clamp technique, the involvement of epoxygenases in immunomodulatory drug glutoxim regulation of Na+ transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with epoxygenase inhibitors econazole or proadifen almost completely inhibits the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of the enzymes and/or products of epoxygenase oxidation pathway of arachidonic acid metabolism in glutoxim effect on Na+ transport in frog skin epithelium.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Oxidorreductasas
/
Piel
/
Sodio
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Econazol
/
Inhibidores Enzimáticos
Límite:
Animals
Idioma:
En
Revista:
Dokl Biochem Biophys
Asunto de la revista:
BIOFISICA
/
BIOQUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA