Significantly Improved Pharmacokinetics Enhances <i>In Vivo</i> Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis.

Zhao, Yanan; Lee, Min Hee; Paderu, Padmaja; Lee, Annie; Jimenez-Ortigosa, Cristina; Park, Steven; Mansbach, Robert S; Shaw, Karen Joy; Perlin, David S

Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis.

Zhao, Yanan; Lee, Min Hee; Paderu, Padmaja; Lee, Annie; Jimenez-Ortigosa, Cristina; Park, Steven; Mansbach, Robert S; Shaw, Karen Joy; Perlin, David S.

Afiliación

Zhao Y; Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA zhaoy1@njms.rutgers.edu perlinds@njms.rutgers.edu.
Lee MH; Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Paderu P; Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Lee A; Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Jimenez-Ortigosa C; Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Park S; Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Mansbach RS; Amplyx Pharmaceuticals, Inc., San Diego, California, USA.
Shaw KJ; Amplyx Pharmaceuticals, Inc., San Diego, California, USA.
Perlin DS; Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA zhaoy1@njms.rutgers.edu perlinds@njms.rutgers.edu.

Antimicrob Agents Chemother ; 62(10)2018 10.

Article en En | MEDLINE | ID: mdl-30012766

Asunto(s)

Candidiasis Invasiva/tratamiento farmacológico; Candidiasis/tratamiento farmacológico; Equinocandinas/farmacocinética; Animales; Antifúngicos/farmacocinética; Antifúngicos/uso terapéutico; Candida albicans/efectos de los fármacos; Candida albicans/patogenicidad; Candida glabrata/efectos de los fármacos; Candida glabrata/patogenicidad; Candidiasis/metabolismo; Candidiasis Invasiva/metabolismo; Modelos Animales de Enfermedad; Equinocandinas/uso terapéutico; Masculino; Ratones; Pruebas de Sensibilidad Microbiana

Palabras clave

1-aminobenzotriazole; APX001; APX001A; Candida; efficacy; pharmacokinetics

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidiasis / Equinocandinas / Candidiasis Invasiva Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google