Spontaneous brain activity and connectivity in female patients with temporomandibular joint synovitis pain: a pilot functional magnetic resonance imaging study.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 126(4): 363-374, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30037632
ABSTRACT
OBJECTIVE:
It has been proposed that mechanisms in the central nervous system contribute to the development and maintenance of pain in temporomandibular disorders. In this study, we tested whether spontaneous brain activity and functional connectivity (FC) were altered in patients with temporomandibular joint synovitis pain. STUDYDESIGN:
A prospective, cross-sectional design was adopted. Each of 8 patients and 10 healthy controls (HCs) underwent 2 sessions of functional magnetic resonance imaging mouth closed and mouth open (painful for patients). Regional homogeneity (ReHo) was used to measure spontaneous brain activity in each participant. Brain areas with altered ReHo in patients compared with HCs were identified, and their FCs with the rest of the brain was examined and compared.RESULTS:
Compared with HCs, patients showed decreased pain-related ReHo in the right anterior insula (rAI). The rAI showed a weaker positive FC with the left middle cingulate cortex (MCC) and a weaker negative FC with the right precuneus in patients compared with HCs. Furthermore, the rAI-MCC FC showed a negative correlation with pain intensity in patients.CONCLUSIONS:
These results provide evidence supporting altered pain-related spontaneous brain activity and functional connectivity in the central nervous system in patients with temporomandibular joint synovitis pain.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinovitis
/
Encéfalo
/
Imagen por Resonancia Magnética
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Síndrome de la Disfunción de Articulación Temporomandibular
Tipo de estudio:
Health_economic_evaluation
/
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol
Año:
2018
Tipo del documento:
Article
País de afiliación:
China