Using optimal combined moderators to define heterogeneity in neural responses to randomized conditions: Application to the effect of sleep loss on fear learning.
Neuroimage
; 181: 718-727, 2018 11 01.
Article
en En
| MEDLINE
| ID: mdl-30041060
ABSTRACT
Comparing the neural outcomes of two randomized experimental groups is a primary aim of many functional neuroimaging studies. However, between-group effects can be obscured by heterogeneity in neural responses. Optimal Combined Moderator (OCM) approaches have previously been used to clarify heterogeneity in clinical outcomes following treatment randomization. We show that OCMs can also be used to clarify heterogeneity in the effect of a randomized experimental condition on neural responses. In 78 healthy adults aged 18-30 from the Effects of Dose-Dependent Sleep Disruption on Fear and Reward (SFeRe) study, we used demographic, clinical, genetic, and polysomnographic characteristics to develop OCMs for the effect of a randomized sleep restriction (SR) versus normal sleep (NS) condition on blood-oxygen-level dependent responses in the right amygdala (RAmyg) and subgenual anterior cingulate cortex (sgACC) during fear conditioning (FC) and extinction (FE) paradigms. The OCM for the RAmyg during FE was strongest [r (95% CI)â¯=â¯0.52 (0.42, 0.68)], withstood cross-validation, and divided the sample into two subgroups with opposing experimental effects. Among Nâ¯=â¯48 participants ("SRâ¯<â¯NS"), those with SR exhibited less RAmyg activation during FE than those with NS [d (95%CI)â¯=â¯-1.10 (-1.86, -0.77)]. Among the remaining Nâ¯=â¯30 participants ("SRâ¯>â¯NS"), those with SR exhibited greater RAmyg activation during FE following SR than those with NS [d (95%CI)â¯=â¯0.87 (0.37,1.78)]. SRâ¯>â¯NS participants were more likely to be female, white, l/l genotype carriers, and have a psychiatric history. They had less sleep (overall and in REM), lower REM density, and lower spindle activity (12-16â¯Hz). Applying OCMs to randomized studies with neural outcomes can clarify neural heterogeneity and jumpstart mechanistic research; with further validation they also offer promise for personalized brain-based treatments and interventions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sueño
/
Privación de Sueño
/
Condicionamiento Clásico
/
Miedo
/
Neuroimagen Funcional
/
Genotipo
/
Giro del Cíngulo
/
Amígdala del Cerebelo
/
Trastornos Mentales
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuroimage
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2018
Tipo del documento:
Article