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In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin.
Grillo, Mark P; Erve, John C L; Dick, Ryan; Driscoll, James P; Haste, Nicole; Markova, Svetlana; Brun, Priscilla; Carlson, Timothy J; Evanchik, Marc.
Afiliación
  • Grillo MP; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
  • Erve JCL; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
  • Dick R; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
  • Driscoll JP; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
  • Haste N; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
  • Markova S; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
  • Brun P; b Sanofi-Aventis Recherche et Développement , Montpellier , France.
  • Carlson TJ; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
  • Evanchik M; a Department of Drug Metabolism and Pharmacokinetics , MyoKardia, Inc , South San Francisco , CA , USA.
Xenobiotica ; 49(6): 718-733, 2019 Jun.
Article en En | MEDLINE | ID: mdl-30044681
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uracilo / Bencilaminas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Xenobiotica Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uracilo / Bencilaminas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Xenobiotica Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos