Structure of ScpC, a virulence protease from <i>Streptococcus pyogenes</i>, reveals the functional domains and maturation mechanism.

Jobichen, Chacko; Tan, Ying Chong; Prabhakar, Mahalakshmi Tirumuru; Nayak, Digant; Biswas, Debabrata; Pannu, Navraj S; Hanski, Emanuel; Sivaraman, J

Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism.

Jobichen, Chacko; Tan, Ying Chong; Prabhakar, Mahalakshmi Tirumuru; Nayak, Digant; Biswas, Debabrata; Pannu, Navraj S; Hanski, Emanuel; Sivaraman, J.

Afiliación

Jobichen C; Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543.
Tan YC; Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543.
Prabhakar MT; Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543.
Nayak D; Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543.
Biswas D; Singapore - HUJ Alliance for Research and Enterprise, CREATE, Molecular Mechanisms Underlying Inflammatory Diseases (MMID), National University of Singapore, 1CREATE Way, Singapore.
Pannu NS; Biophysical Structural Chemistry, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands.
Hanski E; Singapore - HUJ Alliance for Research and Enterprise, CREATE, Molecular Mechanisms Underlying Inflammatory Diseases (MMID), National University of Singapore, 1CREATE Way, Singapore.
Sivaraman J; Department of Microbiology and Molecular Genetics, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Biochem J ; 475(17): 2847-2860, 2018 09 11.

Article en En | MEDLINE | ID: mdl-30049896

Asunto(s)

Proteínas Bacterianas/química; Serina Endopeptidasas/química; Streptococcus pyogenes/enzimología; Streptococcus pyogenes/patogenicidad; Factores de Virulencia/química; Proteínas Bacterianas/genética; Cristalografía por Rayos X; Dominios Proteicos; Serina Endopeptidasas/genética; Streptococcus pyogenes/genética; Factores de Virulencia/genética

Palabras clave

Streptococcus pyogenes; crystallography; protease maturation; serine proteases

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptococcus pyogenes / Proteínas Bacterianas / Serina Endopeptidasas / Factores de Virulencia Idioma: En Revista: Biochem J Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido

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