Cardiac and autonomic function in patients with Crohn's disease during remission.
Adv Med Sci
; 63(2): 334-340, 2018 Sep.
Article
en En
| MEDLINE
| ID: mdl-30053718
ABSTRACT
PURPOSE:
The aim of the study was to assess cardiac and autonomic function in patients with Crohn's disease and explore their relation to disease duration using cardiovascular reflex tests. MATERIALS ANDMETHODS:
Cardiovascular parameters, baroreflex sensitivity, spectral-indices of short-term heart rate variability and blood pressure variability were compared between patients with Crohn's disease in remission (nâ¯=â¯30) and a control group (nâ¯=â¯29). Cardiac autonomic function was assessed during response to standing (tilt) and deep breathing test (expiration/inspiration ratio-E/I). Aortic pulse wave velocity, aortic augmentation index and central systolic blood pressure were measured oscillometrically.RESULTS:
At rest, Crohn's disease patients had significantly higher systolic (pâ¯=â¯0.03) and diastolic (pâ¯=â¯0.03) blood pressure, total peripheral resistance index (pâ¯=â¯0.003), sympathetic-parasympathetic ratio (pâ¯=â¯0.033) and lower baroreceptor effectiveness (pâ¯=â¯0.047), myocardial variables (stroke index; pâ¯=â¯0.03, cardiac index; pâ¯=â¯0.025, Heather index; pâ¯=â¯0.039, left ventricular ejection time; pâ¯=â¯0.038), as compared to controls. Orthostatic response to the tilt test in the Crohn's disease group and the control group was similar, no intergroup differences were observed for E/I ratio and autonomic parameters. In Crohn's disease patients, disease duration was negatively associated with baroreflex sensitivity and positively correlated with normalised high frequency heart rate variability, sympathetic-parasympathetic ratio at rest and post-tilt changes in Δsystolic blood pressure, pâ¯<â¯0.05. The control group had significantly lower central systolic blood pressure (pâ¯=â¯0.043) compared to Crohn's disease patients.CONCLUSIONS:
Crohn's disease patients in remission have preserved cardiac and autonomic function in response to cardiovascular reflex tests with a shift in cardiovascular autonomic regulation towards sympathetic predominate in the rest position.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Autónomo
/
Enfermedad de Crohn
/
Corazón
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Adv Med Sci
Asunto de la revista:
MEDICINA
Año:
2018
Tipo del documento:
Article