[Interaction of thymosin fraction 3 with opiate receptors]. / Vzaimodeistvie tret'ei fraktsii timozina s opiatnymi retseptorami.

ABSTRACT

Using the radioreceptor method thymosin fraction 3 was demonstrated to displace 3H-morphine and 3H-naloxone from opiate receptor of crude membrane fraction of the rat brain. The value of EC50 ratio in the presence and absence of 100 mM NaCl seems to indicate that thymosin contains one or several partial agonists of morphine. Furthermore, the peptide nature of these ligands is suggested on the basis of enzymatic treatment data. The possible role of opioid peptides in the realization of thymus endocrine functions is discussed.