Clinical and economic impact of the taurolidine lock on home parenteral nutrition.
Nutr Hosp
; 35(4): 761-766, 2018 Jun 28.
Article
en En
| MEDLINE
| ID: mdl-30070861
ABSTRACT
INTRODUCTION:
catheter-related bloodstream infections (CRBSI) are one of the most serious concerns in patients on home parenteral nutrition (HPN) which involve high morbidity and cost for the healthcare system. In the last years, taurolidine lock has proven to be beneficial in the prevention of CRBSI; however, the evidence of its efficiency is limited.OBJECTIVE:
to determine if taurolidine lock is a cost-effective intervention in patients on HPN. MATERIALS ANDMETHODS:
retrospective study in patients on HPN with taurolidine lock. We compared the CRBSI rate and cost of its complications before and during taurolidine lock.RESULTS:
thirteen patients, six (46%) males and seven (54%) females, with a mean age of 61.08 (SD = 14.18) years received taurolidine lock. The total days of catheterization pre and per-taurolidine were 12,186 and 5,293, respectively. The underlying disease was benign in five patients (38.5%) and malignant in eight (61.5%). The CRBSI rate pre vs per-taurolidine was 3.12 vs 0.76 episodes per 1,000 catheter days (p = 0.0058). When the indication was a high CRBSI rate, this was 9.72 vs 0.39 (p < 0.001) in pre and per-taurolidine period respectively. No differences have been observed in the occlusion rates. None of the patients reported any adverse effects. The total cost of CRBSI in the pre-taurolidine period was 151,264.14 euros vs 24,331.19 euros in the per-taurolidine period.CONCLUSIONS:
our study shows that taurolidine lock is a cost-effective intervention in patients on HPN with high risk of CRBSI.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Taurina
/
Tiadiazinas
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Nutrición Parenteral en el Domicilio
/
Infecciones Relacionadas con Catéteres
/
Antiinfecciosos
Tipo de estudio:
Health_economic_evaluation
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Nutr Hosp
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2018
Tipo del documento:
Article