Nucleated red blood cells and serum lactate values on days 2 and 5 are associated with mortality and morbidity in VLBW infants.
Wien Med Wochenschr
; 169(3-4): 87-92, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-30084094
ABSTRACT
AIM:
To correlate nucleated red blood cell counts and serum lactate concentrations on day 2 and 5 of life with morbidity and mortality in very low birth weight infants and to determine corresponding cutoff values.METHODS:
Retrospective analysis in a cohort of very low birth weight infants.RESULTS:
250 very low birth weight infants were included in this study. Gestational age ranged from 23 to 35 weeks (mean 29.04) and birth weight was 320-1500â¯g (mean 1047.9). 55 (22%) patients developed intraventricular hemorrhage, 55 (22%) bronchopulmonary dysplasia, 12 (4.8%) periventricular leukomalacia, 93 (37.2%) retinopathy of prematurity, and 1 (0.4%) necrotizing enterocolitis. Mortality rate was 25/250 (10%). Nucleated red blood cells and serum lactate on day 2 of life were associated with mortality (pâ¯< 0.001). Serum lactate on day 5 of life demonstrated an association with retinopathy of prematurity (pâ¯= 0.017), bronchopulmonary dysplasia (pâ¯= 0.044), and intraventricular hemorrhage (pâ¯< 0.001). Cutoff values predicting mortality were >89.5 nucleated red blood cells/100 leucocytes (sensitivity 68.2%, specificity 89.0%) and serum lactate concentrations >8.5â¯mmol/l (sensitivity 69.6%, specificity 93.5%) on day 2 of life.CONCLUSION:
We conclude that both nucleated red blood cell count and serum lactate concentration are valuable biomarkers in predicting important outcome parameters in very low birth weight infants.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mortalidad Infantil
/
Recién Nacido de muy Bajo Peso
/
Recuento de Eritrocitos
/
Lactatos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
Wien Med Wochenschr
Asunto de la revista:
MEDICINA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania