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miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline.
Kao, Yu-Chia; Wang, I-Fang; Tsai, Kuen-Jer.
Afiliación
  • Kao YC; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan. yukanomail2006@yahoo.com.tw.
  • Wang IF; Department of Pediatrics, E-Da Hospital, Kaohsiung 824, Taiwan. yukanomail2006@yahoo.com.tw.
  • Tsai KJ; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan. e_fung0207@hotmail.com.
Int J Mol Sci ; 19(8)2018 Aug 08.
Article en En | MEDLINE | ID: mdl-30096777
Microribonucleic acids (miRNAs) play a pivotal role in numerous aspects of the nervous system and are increasingly recognized as key regulators in neurodegenerative diseases. This study hypothesized that miR-34c, a miRNA expressed in mammalian hippocampi whose expression level can alter the hippocampal dendritic spine density, could induce memory impairment akin to that of patients with Alzheimer's disease (AD) in mice. In this study, we showed that miR-34c overexpression in hippocampal neurons negatively regulated dendritic length and spine density. Hippocampal neurons transfected with miR-34c had shorter dendrites on average and fewer filopodia and spines than those not transfected with miR-34c (control mice). Because dendrites and synapses are key sites for signal transduction and fundamental structures for memory formation and storage, disrupted dendrites can contribute to AD. Therefore, we supposed that miR-34c, through its effects on dendritic spine density, influences synaptic plasticity and plays a key role in AD pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Espinas Dendríticas / Enfermedad de Alzheimer / Trastornos de la Memoria Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2018 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Espinas Dendríticas / Enfermedad de Alzheimer / Trastornos de la Memoria Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2018 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza