The restriction endonuclease Alu I induces chromosomal aberrations and mutations in the hypoxanthine phosphoribosyltransferase locus, but not in the Na+/K+ ATPase locus in V79 hamster cells.
Mutat Res
; 174(1): 71-4, 1986 May.
Article
en En
| MEDLINE
| ID: mdl-3010099
ABSTRACT
The restriction endonuclease Alu I induces chromosomal aberrations and mutations in the hypoxanthine phosphoribosyltransferase (HPRT) locus as measured by 6-thioguanine resistance (TGr) in V79 hamster cells. Alu I does not induce mutations in the Na+/K+ ATPase locus as measured by ouabain resistance (OUAr). The data are interpreted to mean that most if not all Alu I-induced TGr mutations represent chromosomal aberrations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desoxirribonucleasas de Localización Especificada Tipo II
/
Enzimas de Restricción del ADN
/
Aberraciones Cromosómicas
/
ATPasa Intercambiadora de Sodio-Potasio
/
Hipoxantina Fosforribosiltransferasa
/
Mutación
Límite:
Animals
Idioma:
En
Revista:
Mutat Res
Año:
1986
Tipo del documento:
Article