Synthesis of new fluorinated proline analogues from polyfluoroalkyl ß-ketoacetals and ethyl isocyanoacetate.

Tolmachova, Nataliya A; Kondratov, Ivan S; Dolovanyuk, Violetta G; Pridma, Stanislav O; Chernykh, Anton V; Daniliuc, Constantin G; Haufe, Günter

Tolmachova, Nataliya A; Kondratov, Ivan S; Dolovanyuk, Violetta G; Pridma, Stanislav O; Chernykh, Anton V; Daniliuc, Constantin G; Haufe, Günter.

Afiliación

Tolmachova NA; Enamine Ltd, Chervonotkatska Str. 78, Kyiv, 02094, Ukraine. n.tolmachova@mail.enamine.net.

Chem Commun (Camb) ; 54(69): 9683-9686, 2018 Aug 23.

Article en En | MEDLINE | ID: mdl-30101963

ABSTRACT

ABSTRACT

The reaction of trifluoroaldol acetal and other polyfluoroalkyl ß-ketoacetals with ethyl isocyanoacetate was applied for the preparation of hitherto unknown fluorinated amino acids, cis- and trans-3-CF3/C2F5-prolines as well as trans-3-CF2Br/CF2Cl/CHF2-3-hydroxyprolines.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Ucrania

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