Cardiac-specific knockout of Lmod2 results in a severe reduction in myofilament force production and rapid cardiac failure.

Pappas, Christopher T; Farman, Gerrie P; Mayfield, Rachel M; Konhilas, John P; Gregorio, Carol C

Pappas, Christopher T; Farman, Gerrie P; Mayfield, Rachel M; Konhilas, John P; Gregorio, Carol C.

Afiliación

Pappas CT; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA; Department of Physiology and Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ, USA. Electronic address: ctpappas@email.arizona.edu.
Farman GP; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA; Department of Physiology and Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ, USA.
Mayfield RM; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA; Department of Physiology and Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ, USA.
Konhilas JP; Department of Physiology and Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ, USA.
Gregorio CC; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA; Department of Physiology and Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ, USA.

J Mol Cell Cardiol ; 122: 88-97, 2018 09.

Article en En | MEDLINE | ID: mdl-30102883

Asunto(s)

Proteínas del Citoesqueleto/genética; Insuficiencia Cardíaca/genética; Contracción Muscular/genética; Proteínas Musculares/genética; Miofibrillas/patología; Análisis de Varianza; Animales; Calcio/metabolismo; Ecocardiografía; Técnicas de Inactivación de Genes; Insuficiencia Cardíaca/patología; Modelos Lineales; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Miocitos Cardíacos/metabolismo; Sarcómeros/patología; Disfunción Ventricular Izquierda/diagnóstico por imagen

Palabras clave

Actin-thin filaments; Cardiomyopathy; Sarcomere

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas del Citoesqueleto / Insuficiencia Cardíaca / Contracción Muscular / Proteínas Musculares / Miofibrillas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Mol Cell Cardiol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido

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