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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
Fensome, Andrew; Ambler, Catherine M; Arnold, Eric; Banker, Mary Ellen; Brown, Matthew F; Chrencik, Jill; Clark, James D; Dowty, Martin E; Efremov, Ivan V; Flick, Andrew; Gerstenberger, Brian S; Gopalsamy, Ariamala; Hayward, Matthew M; Hegen, Martin; Hollingshead, Brett D; Jussif, Jason; Knafels, John D; Limburg, David C; Lin, David; Lin, Tsung H; Pierce, Betsy S; Saiah, Eddine; Sharma, Raman; Symanowicz, Peter T; Telliez, Jean-Baptiste; Trujillo, John I; Vajdos, Felix F; Vincent, Fabien; Wan, Zhao-Kui; Xing, Li; Yang, Xiaojing; Yang, Xin; Zhang, Liying.
Afiliación
  • Fensome A; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Ambler CM; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Arnold E; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Banker ME; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Brown MF; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Chrencik J; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Clark JD; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Dowty ME; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Efremov IV; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Flick A; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Gerstenberger BS; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Gopalsamy A; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Hayward MM; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Hegen M; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Hollingshead BD; Drug Safety Research and Development, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Jussif J; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Knafels JD; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Limburg DC; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Lin D; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Lin TH; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Pierce BS; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Saiah E; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Sharma R; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Symanowicz PT; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Telliez JB; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Trujillo JI; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Vajdos FF; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Vincent F; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Wan ZK; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Xing L; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Yang X; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
  • Yang X; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Zhang L; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
J Med Chem ; 61(19): 8597-8612, 2018 10 11.
Article en En | MEDLINE | ID: mdl-30113844
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Experimental / Pirazoles / Pirimidinas / Tuberculosis / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 / TYK2 Quinasa / Mycobacterium tuberculosis / Antituberculosos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Experimental / Pirazoles / Pirimidinas / Tuberculosis / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 / TYK2 Quinasa / Mycobacterium tuberculosis / Antituberculosos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos