Targeting the Tie2-&#945;<sub>v</sub>ß<sub>3</sub> integrin axis with bi-specific reagents for the inhibition of angiogenesis.

Shlamkovich, Tomer; Aharon, Lidan; Koslawsky, Dana; Einav, Yulia; Papo, Niv

Targeting the Tie2-α_vß₃ integrin axis with bi-specific reagents for the inhibition of angiogenesis.

Shlamkovich, Tomer; Aharon, Lidan; Koslawsky, Dana; Einav, Yulia; Papo, Niv.

Afiliación

Shlamkovich T; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel.
Aharon L; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel.
Koslawsky D; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel.
Einav Y; Faculty of Engineering, Holon Institute of Technology, Holon, Israel.
Papo N; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel. papo@bgu.ac.il.

BMC Biol ; 16(1): 92, 2018 08 17.

Article en En | MEDLINE | ID: mdl-30119679

Asunto(s)

Inhibidores de la Angiogénesis/farmacología; Neovascularización Fisiológica/genética; Receptor TIE-2/antagonistas & inhibidores; Receptores de Vitronectina/genética; Ribonucleasa Pancreática/antagonistas & inhibidores; Inhibidores de la Angiogénesis/química; Animales; Ratones; Receptor TIE-2/química; Receptor TIE-2/genética; Receptor TIE-2/metabolismo; Receptores de Vitronectina/química; Receptores de Vitronectina/metabolismo; Ribonucleasa Pancreática/química; Ribonucleasa Pancreática/genética; Ribonucleasa Pancreática/metabolismo

Palabras clave

Angiogenesis; Bi-specific proteins; Directed evolution; Integrins; Protein engineering; Receptor tyrosine kinases

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleasa Pancreática / Receptores de Vitronectina / Neovascularización Fisiológica / Inhibidores de la Angiogénesis / Receptor TIE-2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: BMC Biol Asunto de la revista: BIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido

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