Levodopa-Reduced Mucuna pruriens Seed Extract Shows Neuroprotective Effects against Parkinson's Disease in Murine Microglia and Human Neuroblastoma Cells, Caenorhabditis elegans, and Drosophila melanogaster.

Johnson, Shelby L; Park, Hyun Y; DaSilva, Nicholas A; Vattem, Dhiraj A; Ma, Hang; Seeram, Navindra P

Levodopa-Reduced Mucuna pruriens Seed Extract Shows Neuroprotective Effects against Parkinson's Disease in Murine Microglia and Human Neuroblastoma Cells, Caenorhabditis elegans, and Drosophila melanogaster.

Johnson, Shelby L; Park, Hyun Y; DaSilva, Nicholas A; Vattem, Dhiraj A; Ma, Hang; Seeram, Navindra P.

Afiliación

Johnson SL; School of Biotechnology and Health Sciences, Wuyi University; International Healthcare Innovation Institute (Jiangmen), Jiangmen 529020, China. shelby_johnson@uri.edu.
Park HY; Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. shelby_johnson@uri.edu.
DaSilva NA; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA. shelby_johnson@uri.edu.
Vattem DA; Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. parkh4@ohio.edu.
Ma H; School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA. parkh4@ohio.edu.
Seeram NP; Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. ndasilva@my.uri.edu.

Nutrients ; 10(9)2018 Aug 22.

Article en En | MEDLINE | ID: mdl-30131460

Asunto(s)

Levodopa/farmacología; Microglía/efectos de los fármacos; Mucuna/química; Fármacos Neuroprotectores/farmacología; Extractos Vegetales/farmacología; 1-Metil-4-fenilpiridinio/toxicidad; Animales; Caenorhabditis elegans/efectos de los fármacos; Caenorhabditis elegans/metabolismo; Línea Celular Tumoral; Modelos Animales de Enfermedad; Dopaminérgicos/toxicidad; Drosophila melanogaster/efectos de los fármacos; Drosophila melanogaster/metabolismo; Humanos; Masculino; Microglía/metabolismo; Neuroblastoma/metabolismo; Oxidopamina/toxicidad; Enfermedad de Parkinson/tratamiento farmacológico; Especies Reactivas de Oxígeno/metabolismo; Semillas/química

Palabras clave

Caenorhabditis elegans; Drosophila melanogaster; Mucuna pruriens; Parkinson's disease; levodopa; neuroprotection

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Levodopa / Microglía / Fármacos Neuroprotectores / Mucuna Límite: Animals / Humans / Male Idioma: En Revista: Nutrients Año: 2018 Tipo del documento: Article País de afiliación: China

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