Involvement of glutamate receptors of the paragigantocellularis lateralis nucleus in the pain modulatory effect of 17ß-estradiol in male rats.
Acta Neurol Belg
; 120(3): 653-660, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-30132138
ABSTRACT
The pain modulatory role of the paragigantocellularis lateralis nucleus (LPGi) and the 17ß-estradiol has thoroughly been probed. This study investigates the contribution of ionotropic glutamate receptors in pain modulatory effect of intra-LPGi injection of 17ß-estradiol. For this purpose, the LPGi nucleus cannulation was performed and drugs were injected into this nucleus, 15 min prior to the formalin test. The duration of formalin-induced flexing and licking behaviors was recorded for 60 min immediately after formalin injection. The results showed that the flexing behavior is significantly decreased by intra-LPGi injection of 0.8 µmol 17ß-estradiol duringboth phases of formalin test (P < 0.001). However, 17ß-estradiol attenuated the licking duration only in the second phase (P < 0.001). Interestingly, NMDA and AMPA/kainate receptor antagonists (AP5 and CNQX, respectively) significantly counteracted the analgesic effect of intra-LPGi injection of 17ß-estradiol in both phases of the formalin test (P < 0.001). Consequently, the revealing results showed that the analgesic effect of intra-LPGi injection of 17ß-estradiol on acute inflammatory pain might be mediated via the activation of ionotropic glutamate receptors.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Bulbo Raquídeo
/
Receptores de N-Metil-D-Aspartato
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Receptores AMPA
/
Estradiol
Límite:
Animals
Idioma:
En
Revista:
Acta Neurol Belg
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irán