Correlation between serum cryptococcal antigen titre and meningitis in immunocompetent patients.
J Med Microbiol
; 67(10): 1515-1518, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30136919
ABSTRACT
The aim of this paper was to determine the correlation between serum cryptococcal antigen and a diagnosis of cryptococcal meningitis in the immunocompetent cohort. A retrospective multicentre analysis of immunocompetent patients diagnosed and treated for cryptococcal meningitis between January 2000 and December 2017 was performed. Sixty-seven of the 143 cases of cryptococcosis occurred in immunocompetent patients. The serum cryptococcal antigen titre was significantly higher in the meningitis group [1ââ256 (IQR 64-1024)] compared with that for non-meningitis patients [1ââ64 (IQR 8-256)], P=0.012. The relative risk of meningitis with a serum cryptococcal antigen (CRAG) >1ââ64 was 1.8 (95â% CI 1.15-2.82). This study demonstrates a clear correlation between serum cryptococcal antigen titre and meningitis. While the serum titre is not definitive for meningitis, in resource-limited settings or cases where lumbar puncture may be contraindicated, this evidence may aid diagnosis and subsequent therapeutic decisions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Meningitis Criptocócica
/
Cryptococcus
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Antígenos Fúngicos
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Med Microbiol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Australia