Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.
J Exp Med
; 215(10): 2567-2585, 2018 10 01.
Article
en En
| MEDLINE
| ID: mdl-30143481
ABSTRACT
Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN immunity. We report a 5-yr-old child with severe pulmonary influenza at 2 yr. She is homozygous for a loss-of-function IRF9 allele. Her cells activate gamma-activated factor (GAF) STAT1 homodimers but not IFN-stimulated gene factor 3 (ISGF3) trimers (STAT1/STAT2/IRF9) in response to IFN-α2b. The transcriptome induced by IFN-α2b in the patient's cells is much narrower than that of control cells; however, induction of a subset of IFN-stimulated gene transcripts remains detectable. In vitro, the patient's cells do not control three respiratory viruses, influenza A virus (IAV), parainfluenza virus (PIV), and respiratory syncytial virus (RSV). These phenotypes are rescued by wild-type IRF9, whereas silencing IRF9 expression in control cells increases viral replication. However, the child has controlled various common viruses in vivo, including respiratory viruses other than IAV. Our findings show that human IRF9- and ISGF3-dependent type I and III IFN responsive pathways are essential for controlling IAV.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Orthomyxoviridae
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Neumonía Viral
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Alelos
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Subunidad gamma del Factor 3 de Genes Estimulados por el Interferón
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Gripe Humana
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Homocigoto
Límite:
Female
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Humans
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Infant
Idioma:
En
Revista:
J Exp Med
Año:
2018
Tipo del documento:
Article