Is arterial calcification in children and adolescents with end-stage renal disease a rare finding?
Nephrology (Carlton)
; 24(7): 696-702, 2019 Jul.
Article
en En
| MEDLINE
| ID: mdl-30146772
ABSTRACT
AIM:
To investigate if calcification and intimal media thickness (IMT) of arteries are present in children and adolescents with end-stage renal disease and to describe the risk factors associated with these alterations.METHODS:
In an observational, cross-sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification. Two outcomes were considered the presence of calcium deposition and the measurement of the IMT of the artery. The potential exposure variables were age, chronic kidney disease aetiology, diagnosis time, systolic blood pressure (SBP), use of oral active vitamin D, homocysteine and C-reactive protein.RESULTS:
No arterial calcification was observed in the studied sample. The median value of the IMT of the inferior epigastric artery was 166 µm (interquartile range = 130-208). SBP standard deviation score and age were the only factors associated with this outcome. There was no statistical interaction between SBP and age with the IMT (P = 0.280).CONCLUSION:
Arterial calcification is rare in children and adolescents with end-stage renal disease. The factors associated with IMT were age and SBP.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calcificación Vascular
/
Fallo Renal Crónico
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nephrology (Carlton)
Asunto de la revista:
NEFROLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil