Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration.
Acta Neuropathol Commun
; 6(1): 87, 2018 09 05.
Article
en En
| MEDLINE
| ID: mdl-30185219
ABSTRACT
Microglia are brain immune cells that constantly survey their environment to maintain homeostasis. Enhanced microglial reactivity and proliferation are typical hallmarks of neurodegenerative diseases. Whether specific disease-linked microglial subsets exist during the entire course of neurodegeneration, including the recovery phase, is currently unclear. Taking a single-cell RNA-sequencing approach in a susceptibility gene-free model of nerve injury, we identified a microglial subpopulation that upon acute neurodegeneration shares a conserved gene regulatory profile compared to previously reported chronic and destructive neurodegeneration transgenic mouse models. Our data also revealed rapid shifts in gene regulation that defined microglial subsets at peak and resolution of neurodegeneration. Finally, our discovery of a unique transient microglial subpopulation at the onset of recovery may provide novel targets for modulating microglia-mediated restoration of brain health.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Citocinas
/
Análisis de Secuencia de ARN
/
Microglía
/
Enfermedades Neurodegenerativas
/
Recuperación de la Función
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Acta Neuropathol Commun
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania