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Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders.
Hall, Sara; Janelidze, Shorena; Surova, Yulia; Widner, Håkan; Zetterberg, Henrik; Hansson, Oskar.
Afiliación
  • Hall S; Department of Clinical Sciences of Malmö and Lund, Lund University, Lund, Sweden. sara.hall@med.lu.se.
  • Janelidze S; Memory Clinic, Skåne University Hospital, Malmö, Sweden. sara.hall@med.lu.se.
  • Surova Y; Department of Clinical Sciences of Malmö and Lund, Lund University, Lund, Sweden.
  • Widner H; Department of Clinical Sciences of Malmö and Lund, Lund University, Lund, Sweden.
  • Zetterberg H; Neurology Clinic, Skåne University Hospital, SE-205 02, Malmö, Sweden.
  • Hansson O; Department of Clinical Sciences of Malmö and Lund, Lund University, Lund, Sweden.
Sci Rep ; 8(1): 13276, 2018 09 05.
Article en En | MEDLINE | ID: mdl-30185816
ABSTRACT
Inflammation has been implicated in the pathogenesis of Parkinson's disease (PD). We here investigate levels of inflammatory biomarkers in cerebrospinal fluid (CSF) in PD and atypical parkinsonian disorders (APD) compared with neurologically healthy controls. We included 131 patients with PD and 27 PD with dementia (PDD), 24 with multiple system atrophy (MSA), 14 with progressive supranuclear palsy (PSP) and 50 controls, all part of the Swedish BioFINDER study. CSF was analyzed for CRP, SAA, IL-6, IL-8, YKL-40 and MCP-1 (CCL2) as well as α-synuclein (α-syn), tau, tau phosphorylated at Thr181 (P-tau), Aß42 and NfL. In this exploratory study, we found higher levels of the inflammatory biomarker SAA in PDD and MSA compared with controls and PD and higher levels of CRP in PDD and MSA compared with PD. YKL-40 was lower in PD compared with controls. There were multiple positive correlations between the inflammatory markers, α-syn and markers of neuroaxonal injury (NfL and tau). In PD, higher levels of inflammatory biomarkers correlated with worse motor function and cognitive impairment. Thus, inflammatory biomarkers were increased in PDD and MSA. Furthermore, inflammatory biomarkers correlated with more severe disease regarding motor symptoms and cognitive impairment in PD, indicating an association between inflammation and more aggressive disease course. However, the results need confirmation in follow-up studies.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Suecia