[CHANGES OF THE OXIDATIVE STATUS, MITOCHONDRIAL FUNCTION, BLOOD PRESSURE AND INDICATORS OF HEMOSTASIS IN STRESSED ANIMALS AND IN THE CONDITIONS OF NO-SYNTHASE BLOCKADE].
Ross Fiziol Zh Im I M Sechenova
; 102(7): 833-46, 2016 Jul.
Article
en Ru
| MEDLINE
| ID: mdl-30193051
ABSTRACT
Changes in the metabolism of female rats hanging by cervical dorsal skin fold within 24 hours were examined. It was found that stress exposure results in an increase of the concentration of the final nitric oxide metabolites in the blood serum and homogenates of the heart and brain of animals, intensification of processes peroxidation lipids and mitochondrial dysfunction in these organs. Thus increase of mean arterial blood pressure by 18.9 % from baseline and violation of platelet and plasma components of hemostasis. Inhibitor of neuronal NO-synthase 7-nitroindazole in the dose of 50 mg/kg aggravates of the studied parameters changes. Administration of an animal selective inhibitor of inducible NOS aminoguanidine (50 mg / kg) contributes to limiting the damaging effects of stress reaction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Estrés Oxidativo
/
Inhibidores Enzimáticos
/
Óxido Nítrico Sintasa de Tipo I
/
Óxido Nítrico Sintasa de Tipo II
/
Hemostasis
Límite:
Animals
Idioma:
Ru
Revista:
Ross Fiziol Zh Im I M Sechenova
Asunto de la revista:
FISIOLOGIA
Año:
2016
Tipo del documento:
Article