Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.

Dattaroy, Diptadip; Seth, Ratanesh Kumar; Sarkar, Sutapa; Kimono, Diana; Albadrani, Muayad; Chandrashekaran, Varun; Hasson, Firas Al; Singh, Udai P; Fan, Daping; Nagarkatti, Mitzi; Nagarkatti, Prakash; Diehl, Anna Mae; Chatterjee, Saurabh

Dattaroy, Diptadip; Seth, Ratanesh Kumar; Sarkar, Sutapa; Kimono, Diana; Albadrani, Muayad; Chandrashekaran, Varun; Hasson, Firas Al; Singh, Udai P; Fan, Daping; Nagarkatti, Mitzi; Nagarkatti, Prakash; Diehl, Anna Mae; Chatterjee, Saurabh.

Afiliación

Dattaroy D; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States.
Seth RK; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States.
Sarkar S; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States.
Kimono D; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States.
Albadrani M; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States.
Chandrashekaran V; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States.
Hasson FA; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States.
Singh UP; Department of Pathology Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208, United States.
Fan D; Department of Cell Biology and Anatomy, School of Medicine, USC, Columbia, SC, United States.
Nagarkatti M; Department of Pathology Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208, United States.
Nagarkatti P; Department of Pathology Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC 29208, United States.
Diehl AM; Division of Gastroenterology, Duke University, Durham 27707, United States.
Chatterjee S; Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States. Electronic address: schatt@mailbox.sc.edu.

Eur J Pharmacol ; 841: 33-48, 2018 Dec 15.

Article en En | MEDLINE | ID: mdl-30194936

Asunto(s)

Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Adhesiones Focales/efectos de los fármacos; Compuestos Heterocíclicos de 4 o más Anillos/farmacología; Cirrosis Hepática/tratamiento farmacológico; Receptor Toll-Like 4/metabolismo; Factor de Crecimiento Transformador beta/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Animales; Apoptosis/efectos de los fármacos; Diferenciación Celular/efectos de los fármacos; Línea Celular; Proliferación Celular/efectos de los fármacos; Ciclina E/metabolismo; Transición Epitelial-Mesenquimal/efectos de los fármacos; Fibroblastos/efectos de los fármacos; Fibroblastos/patología; Fibronectinas/metabolismo; Adhesiones Focales/metabolismo; Células Estrelladas Hepáticas/efectos de los fármacos; Células Estrelladas Hepáticas/patología; Compuestos Heterocíclicos de 4 o más Anillos/uso terapéutico; Humanos; Cirrosis Hepática/metabolismo; Cirrosis Hepática/patología; Masculino; Proteínas de la Membrana/metabolismo; Ratones; Ratones Endogámicos C57BL; MicroARNs/genética; Fosfohidrolasa PTEN/metabolismo; Fosforilación/efectos de los fármacos; Factor de Transcripción STAT3/metabolismo; Transducción de Señal/efectos de los fármacos; Fibras de Estrés/efectos de los fármacos; Fibras de Estrés/metabolismo; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

Apoptosis; Cyclin; E Cell cycle; Hedgehog signaling; NAFLD; NASH; TLR4; p21; p53

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Factor de Crecimiento Transformador beta / Adhesiones Focales / Inhibidor p21 de las Quinasas Dependientes de la Ciclina / Receptor Toll-Like 4 / Compuestos Heterocíclicos de 4 o más Anillos / Cirrosis Hepática Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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