Conjugation of antifungal benzoic acid derivatives as a path for detoxification in Penicillium brasilianum, an endophyte from Melia azedarach.
Bioorg Chem
; 81: 367-372, 2018 12.
Article
en En
| MEDLINE
| ID: mdl-30196206
ABSTRACT
In this study, the consumption of 4-bromobenzoic acid and 4-chlorobenzoic acid by the fungus Penicillium brasilianum, an endophyte from Melia azedarach is evaluated. This fungus metabolizes these halobenzoic acids to produce three new brominated compounds, which have been isolated and characterized, and three new chlorinated derivatives identified by HRMS. Among these products, (4-bromobenzoyl)proline has been also chemically synthesized and employed in biological assays, thus providing insights for the elucidation of the defense mechanism of P. brasilianum towards these halobenzoic acids.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Penicillium
/
Bromobenzoatos
/
Clorobenzoatos
/
Melia azedarach
/
Endófitos
/
Antifúngicos
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Bioorg Chem
Año:
2018
Tipo del documento:
Article