An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics.
Anesth Analg
; 130(1): e1-e4, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-30198930
ABSTRACT
The understanding of anesthetic side effects on the heart has been hindered by the lack of sophisticated clinical models. Using micropatterned human-induced pluripotent stem cell-derived cardiomyocytes, we obtained cardiac muscle depressant profiles for propofol, etomidate, and our newly identified anesthetic compound KSEB01-S2. Propofol was the strongest depressant among the 3 compounds tested, exhibiting the largest decrease in contraction velocity, depression rate, and beating frequency. Interestingly, KSEB01-S2 behaved similarly to etomidate, suggesting a better cardiac safety profile. Our results provide a proof-of-concept for using human-induced pluripotent stem cell-derived cardiomyocytes as an in vitro platform for future drug design.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propofol
/
Anestésicos Intravenosos
/
Miocitos Cardíacos
/
Etomidato
/
Células Madre Pluripotentes Inducidas
/
Cardiopatías
/
Frecuencia Cardíaca
/
Contracción Miocárdica
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anesth Analg
Año:
2020
Tipo del documento:
Article