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Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.
Laisk, Triin; Kukuskina, Viktorija; Palmer, Duncan; Laber, Samantha; Chen, Chia-Yen; Ferreira, Teresa; Rahmioglu, Nilufer; Zondervan, Krina; Becker, Christian; Smoller, Jordan W; Lippincott, Margaret; Salumets, Andres; Granne, Ingrid; Seminara, Stephanie; Neale, Benjamin; Mägi, Reedik; Lindgren, Cecilia M.
Afiliación
  • Laisk T; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
  • Kukuskina V; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Palmer D; Competence Centre on Health Technologies, Tartu, Estonia.
  • Laber S; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Chen CY; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Ferreira T; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Rahmioglu N; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
  • Zondervan K; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Becker C; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Lippincott M; Broad Institute of MIT and Harvard, Boston, Massachusetts, USA.
  • Salumets A; Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK.
  • Granne I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Seminara S; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Neale B; Oxford Endometriosis CaRe Centre, Nuffield Department of Women's and Reproductive Health, University of Oxford, UK.
  • Mägi R; Oxford Endometriosis CaRe Centre, Nuffield Department of Women's and Reproductive Health, University of Oxford, UK.
  • Lindgren CM; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Hum Mol Genet ; 27(24): 4323-4332, 2018 12 15.
Article en En | MEDLINE | ID: mdl-30202859
ABSTRACT
The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association with the FSHB locus and identified four additional novel signals in, or near, the GNRH1, PGR, NR5A2 and INS-IGF2 genes. These findings not only confirm the role of the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Factor II del Crecimiento Similar a la Insulina / Predisposición Genética a la Enfermedad / Ciclo Menstrual Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estonia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Factor II del Crecimiento Similar a la Insulina / Predisposición Genética a la Enfermedad / Ciclo Menstrual Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estonia