Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygenglucose deprivation.
Mol Med Rep
; 18(5): 4417-4427, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-30221704
ABSTRACT
Ginkgolide B (GB) and ginkgolide K (GK) are two main active monomers of ginkgolides that present a unique group of diterpenes found naturally in the leaves of the Ginkgo biloba tree. Astrocytes are the most abundant cell type within the central nervous system (CNS) and serve essential roles in maintaining healthy brain function. The present study compared the biological effects of GB and GK on astrocytes exposed to oxygenglucose deprivation (OGD). The results demonstrated that GB and GK exhibit many different actions. The level of the plateletactivating factor (PAF) was elevated on astrocytes exposed to OGD, and inhibited by GB and GK treatment. Although GB and GK inhibited the expression of pNFκB/p65, GK exerted stronger antiinflammatory and antioxidant effects on astrocytes exposed to OGD than GB by inhibiting interleukin (IL)6 and tumor necrosis factorα, and inducing IL10 and the nuclear factorerythroid 2related factor 2/HO1 signaling pathway. When compared with GB treatment, GK treatment maintained high levels of phosphoinositide 3kinase/phosphorylatedprotein kinase B expression, and induced a marked upregulation of Wnt family member 1 and brain derived neurotrophic factor, indicating that GK, as a natural plant compound, may have more attractive prospects for clinical application in the treatment of neurological disorders than GB.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Ginkgólidos
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Lactonas
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Enfermedades del Sistema Nervioso
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Antioxidantes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Med Rep
Año:
2018
Tipo del documento:
Article