MicroRNAs as Regulators of Prostate Cancer Metastasis.
Adv Exp Med Biol
; 1095: 83-100, 2018.
Article
en En
| MEDLINE
| ID: mdl-30229550
ABSTRACT
Prostate cancer causes significant morbidity in men and metastatic disease is a major cause of cancer related deaths. Prostate metastasis is controlled by various cellular intrinsic and extrinsic factors, which are often under the regulatory control of various metastasis-associated genes. Given the dynamic nature of metastatic cancer cells, the various factors controlling this process are themselves regulated by microRNAs which are small non-coding RNAs. Significant research work has shown differential microRNA expression in primary and metastatic prostate cancer suggesting their importance in prostate pathogenesis. We will review the roles of different microRNAs in controlling the various steps in prostate metastasis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
MicroARNs
/
Metástasis de la Neoplasia
Límite:
Humans
/
Male
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos