Mannoside Glycolipid Conjugates Display Antiviral Activity Against Ebola Virus.
J Infect Dis
; 218(suppl_5): S666-S671, 2018 11 22.
Article
en En
| MEDLINE
| ID: mdl-30239745
ABSTRACT
The West African outbreak of Ebola virus (EBOV) infection during 2013-2016 highlighted the need for development of field-applicable therapeutic drugs for this infection. Here we report that mannoside glycolipid conjugates (MGCs) consisting of a trimannose head and a lipophilic chain assembled by a linker inhibit EBOV infection not only of human monocyte-derived dendritic cells and macrophages, but also of a number of susceptible cells. Analysis of the mode of action leads us to conclude that MGCs act directly on cells, notably by preventing virus endocytosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Glucolípidos
/
Ebolavirus
/
Manósidos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia