Cytoskeletal Contribution to Cell Stiffness Due to Osmotic Swelling; Extending the Donnan Equilibrium.
Curr Top Membr
; 81: 83-96, 2018.
Article
en En
| MEDLINE
| ID: mdl-30243441
ABSTRACT
Cell volume regulation is commonly analyzed with a model of a closed semipermeable membrane filled with impermeant mobile solutes and the Donnan Equilibrium is used to predict the hydrostatic pressure. This traditional model ignores the fact that most cells are filled with a crosslinked cytoskeleton that is elastic and can be stretched or compressed like a sponge with no obvious need to move mobile solutes. However, calculations show that under osmotic stress, the elastic energy of the cytoskeleton is far greater than the elastic energy of the membrane. Here we expand the traditional Donnan model to include the elasticity of a cytoskeleton with fixed charges and show that cell stiffening happens without a membrane.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ósmosis
/
Presión Osmótica
/
Citoesqueleto
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Top Membr
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos